Article
Steroidogenic factor 1: an essential mediator of endocrine development.
Recent progress in hormone research - 1 Jan 2002
Parker Keith L, Rice Douglas A, Lala Deepak S, Ikeda Yayoi, Luo Xunrong, Wong Margaret, Bakke Marit, Zhao Liping, Frigeri Claudia, Hanley Neil A, Stallings Nancy, Schimmer Bernard P
Abstract excerpt
The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP and officially designated NR5A1) has emerged as an essential regulator of endocrine development and function. Initially identified as a tissue-specific transcriptional regulator of the cytochrome P450 steroid hydroxylases, SF-1 has considerably broader roles, as evidenced from studies in knockout mice lacking SF-1. The SF-1-knockout mice...
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