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Article

Osteopenia in Siah1a mutant mice.

The Journal of biological chemistry - 9 Jul 2004

Frew Ian J, Sims Natalie A, Quinn Julian M W, Walkley Carl R, Purton Louise E, Bowtell David D L, Gillespie Matthew T

Abstract excerpt

Siah1a has been implicated in numerous signaling pathways because of its ability to induce ubiquitin-mediated degradation of many protein substrates. Siah1a knockout mice are growth-retarded, exhibit early lethality, and display spermatogenic defects. In this study we identified a striking low bone volume phenotype in these mice (trabecular bone volume was halved compared with wild type mice), linking Siah1a to...

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Identifiers

PMID: 15123657
DOI: 10.1074/jbc.M312755200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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