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Article

Cell-Specific Knockout of Steroidogenic Factor 1 Reveals Its Essential Roles in Gonadal Function

3 May 2004

Abstract excerpt

Knockout (KO) mice lacking the orphan nuclear receptor steroidogenic factor 1 (SF-1, officially designated Nr5a1) have a compound endocrine phenotype that includes adrenal and gonadal agenesis, impaired expression of pituitary gonadotropins, and structural abnormalities of the ventromedial hypothalamic nucleus. To inactivate a conditional SF-1 allele in the gonads, we targeted the expression of Cre recombinase...

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Identifiers

PMID: 15118069
DOI: 10.1210/me.2003-0404

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Cell-Specific Knockout of Steroidogenic Factor 1 Reveals Its Essential Roles in Gonadal FunctionPMID 15118069Read ↗

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