Article
The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion.
JCI insight - 7 Dec 2017
Scortegagna Marzia, Berthon Annabel, Settas Nikolaos, Giannakou Andreas, Garcia Guillermina, Li Jian-Liang, James Brian, Liddington Robert C, Vilches-Moure José G, Stratakis Constantine A, Ronai Ze'ev A
Abstract excerpt
Primary and secondary hypertension are major risk factors for cardiovascular disease, the leading cause of death worldwide. Elevated secretion of aldosterone resulting from primary aldosteronism (PA) is a key driver of secondary hypertension. Here, we report an unexpected role for the ubiquitin ligase Siah1 in adrenal gland development and PA. Siah1a-/- mice exhibit altered adrenal gland morphology, as reflected...
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