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Article

Derivation and characterization of a dengue type 1 host range-restricted mutant virus that is attenuated and highly immunogenic in monkeys.

Journal of virology - 1 Apr 2002

Markoff Lewis, Pang Xiaou, Houng Hs Huo-shu, Falgout Barry, Olsen Raymond, Jones Estella, Polo Stephanie

Abstract excerpt

We recently described the derivation of a dengue serotype 2 virus (DEN2mutF) that exhibited a host range-restricted phenotype; it was severely impaired for replication in cultured mosquito cells (C6/36 cells). DEN2mutF virus had selected mutations in genomic sequences predicted to form a 3' stem-loop structure (3'-SL) that is conserved among all flavivirus species. The 3'-SL constitutes the downstream terminal...

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Identifiers

PMID: 11884557
DOI: 10.1128/jvi.76.7.3318-3328.2002
PMCID: PMC136019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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