Article
Identification of specific nucleotide sequences within the conserved 3'-SL in the dengue type 2 virus genome required for replication.
Journal of virology - 1 Sept 1998
Zeng L, Falgout B, Markoff L
Abstract excerpt
The flavivirus genome is a positive-stranded approximately 11-kb RNA including 5' and 3' noncoding regions (NCR) of approximately 100 and 400 to 600 nucleotides (nt), respectively. The 3' NCR contains adjacent, thermodynamically stable, conserved short and long stem-and-loop structures (the 3'-SL), formed by the 3'-terminal approximately 100 nt. The nucleotide sequences within the 3'-SL are not well conserved...
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