Dengue type 4 virus mutants containing deletions in the 3' noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeys.

doi:10.1128/JVI.70.6.3930-3937.1996

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Article

Dengue type 4 virus mutants containing deletions in the 3' noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeys.

Journal of virology - 1 Jun 1996

Men R, Bray M, Clark D, Chanock R M, Lai C J

Abstract excerpt

The dengue type 4 virus (DEN4) genome contains a 384-nucleotide (nt) 3' noncoding sequence in which the last 81 nt, predicted to form a secondary structure, are thought to be essential for virus replication. Immediately upstream of the secondary structure, short RNA sequences that are conserved a...

Topics

Animals
Antibodies, Viral
Base Sequence
Cells, Cultured
DNA, Complementary
Dengue
Dengue Virus
Gene Deletion
Genome, Viral
Macaca mulatta
Molecular Sequence Data
Mutation
RNA, Viral
Viremia

Source

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Identifiers

PMID: 8648730
DOI: 10.1128/JVI.70.6.3930-3937.1996
PMCID: PMC190271

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8648730-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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