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Article

A prM mutation that attenuates dengue virus replication in human cells enhances midgut infection in mosquitoes.

Science translational medicine - 31 Jul 2024

Choi Allyson N X, Siriphanitchakorn Tanamas, Choy Milly M, Ooi Justin S G, Manuel Menchie, Tan Hwee Cheng, Lin Lowell Z, Yap Xin, Gubler Duane J, Ooi Eng Eong

Abstract excerpt

Dengue viruses (DENVs), like all viruses, evolve to perpetuate transmission of their species in their hosts. However, how DENV genetics influences dengue disease outbreaks remains poorly understood. Here, we examined isolates of the South Pacific dengue virus type 2 (DENV-2) that emerged in the 1970s and caused major dengue outbreaks in islands in this region until it reached Tonga, where only a few mild cases...

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Identifiers

PMID: 39083584
DOI: 10.1126/scitranslmed.adk4769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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