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Article

Rational design of a live attenuated dengue vaccine: 2'-o-methyltransferase mutants are highly attenuated and immunogenic in mice and macaques.

PLoS pathogens - 1 Jan 2013

Züst Roland, Dong Hongping, Li Xiao-Feng, Chang David C, Zhang Bo, Balakrishnan Thavamalar, Toh Ying-Xiu, Jiang Tao, Li Shi-Hua, Deng Yong-Qiang, Ellis Brett R, Ellis Esther M, Poidinger Michael, Zolezzi Francesca, Qin Cheng-Feng, Shi Pei-Yong, Fink Katja

Abstract excerpt

Dengue virus is transmitted by Aedes mosquitoes and infects at least 100 million people every year. Progressive urbanization in Asia and South-Central America and the geographic expansion of Aedes mosquito habitats have accelerated the global spread of dengue, resulting in a continuously increasi...

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Identifiers

PMID: 23935499
DOI: 10.1371/journal.ppat.1003521
PMCID: PMC3731252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23935499-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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