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Article

Vaccine candidates derived from a novel infectious cDNA clone of an American genotype dengue virus type 2.

BMC infectious diseases - 4 Oct 2004

Blaney Joseph E, Hanson Christopher T, Hanley Kathryn A, Murphy Brian R, Whitehead Stephen S

Abstract excerpt

BACKGROUND: A dengue virus type 2 (DEN-2 Tonga/74) isolated from a 1974 epidemic was characterized by mild illness and belongs to the American genotype of DEN-2 viruses. To prepare a vaccine candidate, a previously described 30 nucleotide deletion (Delta30) in the 3' untranslated region of DEN-4 has been engineered into the DEN-2 isolate. METHODS: A full-length cDNA clone was generated from the DEN-2 virus and...

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Identifiers

PMID: 15461822
DOI: 10.1186/1471-2334-4-39
PMCID: PMC524489

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