Article
Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells.
Stem cell research & therapy - 10 Apr 2020
Orge Iasmim Diniz, Gadd Victoria L, Barouh Judah Leão, Rossi Erik Aranha, Carvalho Rejane Hughes, Smith Ian, Allahdadi Kyan James, Paredes Bruno Diaz, Silva Daniela Nascimento, Damasceno Patrícia Kauanna F, Sampaio Gabriela Louise, Forbes Stuart J, Soares Milena Botelho Pereira, Souza Bruno Solano de Freitas
Abstract excerpt
BACKGROUND: Hepatocyte-like cells (iHEPs) generated by transcription factor-mediated direct reprogramming of somatic cells have been studied as potential cell sources for the development of novel therapies targeting liver diseases. The mechanisms involved in direct reprogramming, stability after long-term in vitro expansion, and safety profile of reprogrammed cells in different experimental models, however, still...
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