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Article

Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes

22 Jan 2013

Abstract excerpt

BACKGROUND: Dedifferentiation and loss of hepatocyte polarity during primary culture of hepatocytes are major drawbacks for metabolic analyses. As a prominent profibrotic cytokine and potent inducer of epithelial mesenchymal transition (EMT), TGF-β contributes to these processes in liver epithelial cells. Yet, a distinction between culture dependent and TGF-β driven hepatocyte dedifferentiation has not been shown...

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PMID: 23339737
DOI: 10.1186/1478-811x-11-6

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