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Article

Lys(199) mutation of the human angiotensin type 1 receptor differentially affects the binding of surmountable and insurmountable non-peptide antagonists.

Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Sept 2000

Fierens F L, Vanderheyden P M, Gáborik Z, Minh T L, Backer J P, Hunyady L, Ijzerman A, Vauquelin G

Abstract excerpt

Many slow dissociating (insurmountable) non-peptide angiotensin type 1 receptor (AT1) antagonists contain,besides the acidic biphenyltetrazole substructure of losartan, a second acidic group to stabilise antagonist-receptor complexes. To investigate the involved basic amino-acids of the human AT1-receptor, wild-type and mutant receptors were transiently transfected in CHO-K1 cells and characterised by...

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Identifiers

PMID: 11881039
DOI: 10.3317/jraas.2000.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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