Article
Differentiation between binding sites for angiotensin II and nonpeptide antagonists on the angiotensin II type 1 receptors.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 1994
Schambye H T, Hjorth S A, Bergsma D J, Sathe G, Schwartz T W
Abstract excerpt
To characterize binding sites for nonpeptide angiotensin antagonists on the human angiotensin II receptor type 1 (AT1 receptor) we have systematically exchanged segments of the human receptor with corresponding segments from a homologous Xenopus laevis receptor, which does not bind the nonpeptide compounds. Substitution of transmembrane segment VII of the human AT1 receptor dramatically reduced the binding...
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