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Article

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Mar 2002

Westerman Marcus A, Cooper-Blacketer Deirdre, Mariash Ami, Kotilinek Linda, Kawarabayashi Takeshi, Younkin Linda H, Carlson George A, Younkin Steven G, Ashe Karen H

Abstract excerpt

Transgenic mice expressing mutant amyloid precursor proteins (APPs) have provided important new information about the pathogenesis of Alzheimer's disease (AD) histopathology. However, the molecular basis of memory loss in these mice is poorly understood. One of the major impediments has been the difficulty of distinguishing between age-dependent and age-independent behavioral changes. To address this issue we...

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Identifiers

PMID: 11880515
PMCID: PMC6758862

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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