Article
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles.
The Journal of biological chemistry - 22 Dec 2006
Oddo Salvatore, Vasilevko Vitaly, Caccamo Antonella, Kitazawa Masashi, Cribbs David H, LaFerla Frank M
Abstract excerpt
Increasing evidence points to soluble assemblies of aggregating proteins as a major mediator of neuronal and synaptic dysfunction. In Alzheimer disease (AD), soluble amyloid-beta (Abeta) appears to be a key factor in inducing synaptic and cognitive abnormalities. Here we report the novel finding that soluble tau also plays a role in the cognitive decline in the presence of concomitant Abeta pathology. We describe...
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