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Article

Age-dependent cognitive decline in the APP23 model precedes amyloid deposition.

The European journal of neuroscience - 1 Jan 2003

Van Dam Debby, D'Hooge Rudi, Staufenbiel Matthias, Van Ginneken Chris, Van Meir Frans, De Deyn Peter P

Abstract excerpt

Heterozygous APP23 mice, expressing human amyloid-precursor protein with the Swedish double mutation and control littermates, were subjected to behavioral and neuromotor tasks at the age of 6-8 weeks, 3 and 6 months. A hidden-platform Morris-type water maze showed an age-dependent decline of spatial memory capacities in the APP23 model. From the age of 3 months onwards, the APP23 mice displayed major learning and...

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Source

Identifiers

PMID: 12542676
DOI: 10.1046/j.1460-9568.2003.02444.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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