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Article

Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivo model of Alzheimer's disease.

Journal of neuroinflammation - 1 May 2014

Löffler Tina, Flunkert Stefanie, Havas Daniel, Schweinzer Cornelia, Uger Marni, Windisch Manfred, Steyrer Ernst, Hutter-Paier Birgit

Abstract excerpt

BACKGROUND: Beyond cognitive decline, Alzheimer's disease (AD) is characterized by numerous neuropathological changes in the brain. Although animal models generally do not fully reflect the broad spectrum of disease-specific alterations, the APPSL mouse model is well known to display early plaque...

Topics

Alzheimer Disease
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Animals
Cytokines
Disease Models, Animal
Encephalitis
Gene Expression Regulation
Glial Fibrillary Acidic Protein
Hippocampus
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Transgenic

Mutation

Neocortex

Thiobarbituric Acid Reactive Substances

Source

Open in PubMed Open full text

Identifiers

PMID: 24886182
DOI: 10.1186/1742-2094-11-84
PMCID: PMC4108132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-24886182-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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