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Article

Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivo model of Alzheimer's disease.

Journal of neuroinflammation - 1 May 2014

Löffler Tina, Flunkert Stefanie, Havas Daniel, Schweinzer Cornelia, Uger Marni, Windisch Manfred, Steyrer Ernst, Hutter-Paier Birgit

Abstract excerpt

BACKGROUND: Beyond cognitive decline, Alzheimer's disease (AD) is characterized by numerous neuropathological changes in the brain. Although animal models generally do not fully reflect the broad spectrum of disease-specific alterations, the APPSL mouse model is well known to display early plaque formation and to exhibit spatial learning and memory deficits. However, important neuropathological features, such as...

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Identifiers

PMID: 24886182
DOI: 10.1186/1742-2094-11-84
PMCID: PMC4108132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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