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Article

Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer's disease.

Psychopharmacology - 1 Nov 2013

Easton Amy, Sankaranarayanan Sethu, Tanghe An, Terwel Dick, Lin Alan X, Hoque Nina, Bourin Clotilde, Gu Huidong, Ahlijanian Michael, Bristow Linda

Abstract excerpt

RATIONALE: Acetylcholinesterase inhibitors (AChEIs) are approved to treat the symptoms of mild to moderate Alzheimer's disease by restoring acetylcholine levels at synapses where the neurotransmitter has been depleted due to neurodegeneration. This assumption is challenged by more recent clinical studies suggesting the potential for disease-modifying effects of AChEIs as well as in vitro studies showing...

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PMID: 23783773
DOI: 10.1007/s00213-013-3152-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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