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Article

Effect size of reference memory deficits in the Morris water maze in Tg2576 mice.

Behavioural brain research - 1 Sept 2010

Reed Miranda N, Liu Peng, Kotilinek Linda A, Ashe Karen H

Abstract excerpt

The most widely used mouse model of Alzheimer's disease is the Tg2576 (APP(SWE)) model. While general agreement about their neuropathology prevails, disparate results concerning cognitive changes have been reported. To resolve this controversy, we combined Morris water maze data collected over >10 years to determine the extent of memory impairment. APP(SWE) mice exhibited an age-dependent decline in memory, but...

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Identifiers

PMID: 20381538
DOI: 10.1016/j.bbr.2010.03.037
PMCID: PMC2903868

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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