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Early intraneuronal Aβ deposition in the hippocampus of APP transgenic mice

1 Jan 2003

Abstract excerpt

Increasing evidence suggests that intraneuronal amyloid-beta (Abeta) accumulation may be an early event in Alzheimer's disease (AD) pathogenesis. However direct in vivo evidence regarding initial Abeta seeding is missing. Using an APP transgenic mouse model, our sensitive immunocytochemical procedures revealed a novel intraneuronal Abeta deposition in the somas of hippocampal CA1/subiculum neurons far in advance...

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PMID: 12544843
DOI: 10.1097/00001756-200301200-00023

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