Article
No association between susceptibility to multiple sclerosis and HLA-DPB1 alleles in the French Canadian population.
Tissue antigens - 1 Apr 1991
Howell W M, Sage D A, Evans P R, Smith J L, Francis G S, Haegert D G
Abstract excerpt
HLA-DPB1 typing was performed using polymerase chain reaction DNA amplification and sequence-specific oligonucleotide probing (PCR-SSOP) which permitted identification of 17 distinct DPB alleles using 15 oligonucleotide probes. The accuracy of this approach was confirmed in an initial study of 26 human B-lymphoblastoid cell lines which demonstrated close agreement between PCR-SSOP and PLT assigned types. A cohort...
Topics
- Alleles
- Base Sequence
- Canada
- Cohort Studies
- Disease Susceptibility
- Ethnicity
- Genetic Predisposition to Disease
- HLA-DP Antigens
- HLA-DP beta-Chains
- Humans
- Molecular Sequence Data