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Article

Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritis.

Arthritis and rheumatism - 1 Jul 2008

Prahalad Sampath, Bohnsack John F, Whiting April, Clifford Bronte, Jorde Lynn B, Guthery Stephen L, Thompson Susan D, Glass David N, Bamshad Michael J

Abstract excerpt

OBJECTIVE: Juvenile idiopathic arthritis (JIA) is an autoimmune disorder mediated by Th1 immune responses. CTLA-4, expressed on the T cell surface, plays a negative role in regulating T cell activation. Single-nucleotide polymorphisms (SNPs) in CTLA4 have been implicated in susceptibility to several autoimmune disorders, including JIA. This study was undertaken to test 3 functional CTLA4 variants for association...

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Share to Antigens, CD
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18576317
DOI: 10.1002/art.23602
PMCID: PMC2570539

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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