Article
Genotypic correlates of resistance to HIV-1 protease inhibitors on longitudinal data: the role of secondary mutations.
Antiviral therapy - 1 Dec 2001
Servais J, Plesséria J M, Lambert C, Fontaine E, Robert I, Arendt V, Staub T, Schneide F, Hemme R, Schmit J C
Abstract excerpt
Direct sequencing of the pol gene was assessed retrospectively with protease inhibitor susceptibility in a longitudinal study. A total of 134 samples from 26 patients were analysed at regular intervals up to 2 years. Patients were included in virological failure despite indinavir, ritonavir or saquinavir based triple-drug therapy. Both the type and number of certain secondary protease mutations modulated the...
Topics
- Acquired Immunodeficiency Syndrome
- Adult
- CD4 Lymphocyte Count
- Cross-Sectional Studies
- Drug Resistance, Viral
- Female
- Genotype
- HIV Protease
- HIV Protease Inhibitors
- Humans
- Longitudinal Studies