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Article

Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments.

Journal of medical virology - 1 Nov 2007

Garriga César, Pérez-Elías María Jesús, Delgado Rafael, Ruiz Lidia, Nájera Rafael, Pumarola Tomàs, Alonso-Socas María del Mar, García-Bujalance Silvia, Menéndez-Arias Luis

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) antiviral drug resistance is a major consequence of therapy failure and compromises future therapeutic options. Nelfinavir and lopinavir/ritonavir-based therapies have been widely used in the treatment of HIV-infected patients, in combination with reverse transcriptase inhibitors. The aim of this observational study was the identification and characterization of...

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PMID: 17854027
DOI: 10.1002/jmv.20986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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