Article
Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments.
Journal of medical virology - 1 Nov 2007
Garriga César, Pérez-Elías María Jesús, Delgado Rafael, Ruiz Lidia, Nájera Rafael, Pumarola Tomàs, Alonso-Socas María del Mar, García-Bujalance Silvia, Menéndez-Arias Luis
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) antiviral drug resistance is a major consequence of therapy failure and compromises future therapeutic options. Nelfinavir and lopinavir/ritonavir-based therapies have been widely used in the treatment of HIV-infected patients, in combination with reverse transcriptase inhibitors. The aim of this observational study was the identification and characterization of...
Topics
- Amino Acid Substitution
- Databases, Protein
- Drug Resistance, Viral
- HIV Infections
- HIV Protease
- HIV Protease Inhibitors
- HIV-1
- Humans
- Lopinavir
- Models, Molecular
- Mutation
- Nelfinavir
- Pyrimidinones