Article
Resistance testing in children changing human immunodeficiency virus type 1 protease inhibitor.
The Pediatric infectious disease journal - 1 Mar 2002
Servais Jean, Hainaut Marc, Schmitz Véronique, Maes Philip, Fransen Katrien, Vaira Dolores, Brichard Bénédicte, Arendt Vic, Schneider François, Hemmer Robert, Schmit Jean-Claude
Abstract excerpt
OBJECTIVE: To assess genotypic and phenotypic resistance testing in HIV-1-infected children failing a first protease inhibitor (PI) therapy. METHODS: In a multicenter observational study 21 children, ages 3 to 16 years, were given two reverse transcriptase inhibitors and one PI (mainly ritonavir, n = 18). They were subsequently treated with single or dual PI-based therapy (predominantly nelfinavir, n = 10, or...
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