Article
Improving lopinavir genotype algorithm through phenotype correlations: novel mutation patterns and amprenavir cross-resistance.
AIDS (London, England) - 2 May 2003
Parkin Neil T, Chappey Colombe, Petropoulos Christos J
Abstract excerpt
BACKGROUND: Current genotypic algorithms suggest that the HIV-1 protease inhibitors (PI) lopinavir (LPV) and amprenavir (APV) have distinct resistance profiles. However, phenotypic data indicate that cross-resistance is more common than expected. METHODS: Protease genotype (GT) and phenotype (PT) from 1418 patient viruses with reduced PI susceptibility and/or resistance-associated mutations (training data) were...
Topics
- Algorithms
- Carbamates
- Drug Resistance, Viral
- Furans
- Genotype
- HIV Infections
- HIV Protease
- HIV Protease Inhibitors
- HIV-1
- Humans
- Lopinavir
- Mutation
- Phenotype
- Pyrimidinones
- Sulfonamides