Article
Prevalence of HIV protease mutations on failure of nelfinavir-containing HAART: a retrospective analysis of four clinical studies and two observational cohorts.
HIV clinical trials - 1 Jan 2000
Clotet Bonaventura, Ruiz Lidia, Martinez-Picado Javier, Negredo Eugènia, Hill Andrew, Popescu Matei
Abstract excerpt
BACKGROUND: Both D30N and L90M in HIV-1 protease are primary resistance mutations that emerge under nelfinavir drug pressure. Although D30N confers little or no cross-resistance to other protease inhibitors (PIs) and has been shown to allow effective substitution of a second PI, L90M with secondary mutations is involved in broad cross-resistance to the class. Although L90M has been observed rarely to date under...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.