Article
Phenotypic and genotypic analysis of clinical HIV-1 isolates reveals extensive protease inhibitor cross-resistance: a survey of over 6000 samples.
AIDS (London, England) - 16 Jun 2000
Hertogs K, Bloor S, Kemp S D, Van den Eynde C, Alcorn T M, Pauwels R, Van Houtte M, Staszewski S, Miller V, Larder B A
Abstract excerpt
OBJECTIVE: To evaluate in HIV-1 the extent of phenotypic and genotypic antiretroviral drug resistance and cross-resistance towards the protease inhibitors (PIs) saquinavir, ritonavir, indinavir and nelfinavir among a set of patient samples originating from European and US routine clinical practice and submitted for phenotypic drug resistance testing and/or genotypic analysis. The mutational pattern(s) underlying...
Topics
- Amino Acid Substitution
- Drug Resistance, Microbial
- Europe
- Genotype
- HIV Infections
- HIV Protease
- HIV Protease Inhibitors
- HIV-1
- Humans
- Mutation
- Phenotype
- United States
- Viral Load