Article
Lysophosphatidic acid potentiates ACh receptor currents by G-protein-mediated activation of protein kinase C.
Brain research. Molecular brain research - 15 Oct 1997
Nishizaki T, Sumikawa K
Abstract excerpt
The effect of lysophosphatidic acid (lysoPA) on acetylcholine (ACh)-evoked currents was examined using normal and mutant Torpedo nicotinic ACh receptors expressed in Xenopus oocytes. LysoPA enhanced ACh-evoked currents in a washing time- and dose-dependent manner at concentrations of 0.1-3 microM...
Topics
- Animals
- Enzyme Activation
- Evoked Potentials
- GTP-Binding Proteins
- Lysophospholipids
- Mutation
- Patch-Clamp Techniques
- Pertussis Toxin
- Phosphorylation
- Protein Kinase C
- Receptors, Nicotinic
- Signal Transduction
- Torpedo
- Virulence Factors, Bordetella
- Xenopus