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Article

Preactivation permits subsequent stimulation of phospholipase C by G(i)-coupled receptors.

Molecular pharmacology - 1 Apr 2000

Chan J S, Lee J W, Ho M K, Wong Y H

Abstract excerpt

In the complex signal transduction networks involving G protein-coupled receptors there are numerous examples where G(i)-linked receptors augment G(q)-dependent signals. The mechanistic basis of such occurrences is thought to entail signal convergence at phospholipase Cbeta (PLCbeta) via the G protein betagamma-dimers. Herein, we explored the possibility that augmentation by betagamma-dimers requires...

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Source

Identifiers

PMID: 10727515
DOI: 10.1124/mol.57.4.700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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