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Article

ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor.

The Journal of biological chemistry - 5 Sept 2003

Mitchell Rory, Robertson Derek N, Holland Pamela J, Collins Daniel, Lutz Eve M, Johnson Melanie S

Abstract excerpt

G protein-coupled receptors can potentially activate phospholipase D (PLD) by a number of routes. We show here that the native M3 muscarinic receptor in 1321N1 cells and an epitope-tagged M3 receptor expressed in COS7 cells substantially utilize an ADP-ribosylation factor (ARF)-dependent route of PLD activation. This pathway is activated at the plasma membrane but appears to be largely independent of G,...

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Source

Identifiers

PMID: 12799371
DOI: 10.1074/jbc.M305825200

Genes

PLD1
ARF1
ARF6
PLD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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