Article
Associations between common polymorphisms in TP53 and p21WAF1/Cip1 and phenotypic features of breast cancer.
Carcinogenesis - 1 Feb 2002
Powell Brenda L, van Staveren Iris L, Roosken Paul, Grieu Fabienne, Berns Els M J J, Iacopetta Barry
Abstract excerpt
The tumour suppressor gene TP53 and its downstream effector p21 are thought to play major roles in the development of breast cancer. We investigated three common sequence variants in TP53 and p21 for possible associations with the risk of breast cancer and with various phenotypic features of this disease. A total of 351 cases were available for study. Germline DNA obtained from female subjects of similar age but...
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