Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of TP53 and p21 gene polymorphisms in breast cancer biology in a well specified and characterized German cohort.

Journal of cancer research and clinical oncology - 1 Sept 2010

Ebner Florian, Schremmer-Danninger Elisabeth, Rehbock Joachim

Abstract excerpt

OBJECTIVE: Abrogation of the function of TP53 gene is supposed to lead to a more aggressive breast cancer phenotype that produces a less favorable clinical outcome. The p21 gene on chromosome 6p21.2 can be stimulated by an activated TP53 gene. A product of transcription, the p21 protein, an inhibitor of cyclin-dependent kinases, has its function in gene repair and angiogenesis during cell division, and can...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Cohort Studies

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Germany

Share to Tumor Suppressor Protein p53

Share to Young Adult

Source

Identifiers

PMID: 20127253
DOI: 10.1007/s00432-010-0788-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of TP53 and p21 gene polymorphisms in breast cancer biology in a well specified and characterized German cohort.PMID 20127253Read ↗

Associations between common polymorphisms in TP53 and p21WAF1/Cip1 and phenotypic features of breast cancer.Semantic proximity Read ↗

TP53 (rs1042522, rs28934571) and TP21 (rs1801270, rs1059234) Polymorphisms and Risk of Breast Cancer among Rural Women of Maharashtra: Findings from a Hospital Based Case- Control Study.Semantic proximity Read ↗

The novel p21 polymorphism p21G251A is associated with locally advanced breast cancer.Semantic proximity Read ↗

Genetic Modifiers of the p53 Pathway.Semantic proximity Read ↗

TP53 mutations and SNPs as prognostic and predictive factors in patients with breast cancer (Review)Semantic proximity Read ↗

Mutations and polymorphisms of the p21B transcript in breast cancer.Semantic proximity Read ↗

TP53 mutations in breast cancer tumors of patients from Rio de Janeiro, Brazil: association with risk factors and tumor characteristics.Semantic proximity Read ↗

The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.Semantic proximity Read ↗

Analysis of the p21 gene in gliomas.Semantic proximity Read ↗

p53 gene polymorphism and cancer risk: the debate continues.Semantic proximity Read ↗

Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancer.Semantic proximity Read ↗

TP53 and P21 polymorphisms: response to cisplatinum/paclitaxel-based chemotherapy in ovarian cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.