Genetic variation in TP53 and risk of breast cancer in a population-based case control study.

doi:10.1093/carcin/bgm097

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Genetic variation in TP53 and risk of breast cancer in a population-based case control study.

Carcinogenesis - 1 Aug 2007

Sprague Brian L, Trentham-Dietz Amy, Garcia-Closas Montserrat, Newcomb Polly A, Titus-Ernstoff Linda, Hampton John M, Chanock Stephen J, Haines Jonathan L, Egan Kathleen M

Abstract excerpt

Whereas germ line missense mutations in the tumor suppressor gene TP53 are associated with a marked predisposition to breast cancer, single-nucleotide polymorphisms (SNPs) may play a more modest role in breast cancer susceptibility. We examined genetic variation in TP53 in relation to breast cancer risk among women aged 20-74 years in a population-based case-control study in Wisconsin, Massachusetts and New...

Topics

Adolescent
Adult
Aged
Breast Neoplasms
Case-Control Studies
Child
Female
Genetic Predisposition to Disease
Genetic Variation
Genetics, Population
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Menopause

Middle Aged

Neoplasm Invasiveness

Polymorphism, Single Nucleotide

Risk Factors

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 17449902
DOI: 10.1093/carcin/bgm097

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