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Article

Linking TP53 codon 72 and P21 nt590 genotypes to the development of cervical and ovarian cancer.

European journal of cancer (Oxford, England : 1990) - 1 May 2006

Santos Alexandra M, Sousa Hugo, Pinto Daniela, Portela Catarina, Pereira Deolinda, Catarino Raquel, Duarte Isabel, Lopes Carlos, Medeiros Rui

Abstract excerpt

TP53 and its downstream effector gene P21 are two important genes in cell cycle regulation. Genetic alterations on p53 and attenuation of p21 expression result in progression through cell cycle G1 checkpoint, which can lead to cancer development. We analysed the frequency of TP53 codon 72 and 3'UTR P21 polymorphisms in 681 blood samples from 371 cervical cancer patients, 122 ovarian cancer patients and 188...

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PMID: 16542834
DOI: 10.1016/j.ejca.2006.01.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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