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Article

Charge immobilization of skeletal muscle Na+ channels: role of residues in the inactivation linker.

Biophysical journal - 1 Sept 2007

Groome James R, Dice Margaret C, Fujimoto Esther, Ruben Peter C

Abstract excerpt

We investigated structural determinants of fast inactivation and deactivation in sodium channels by comparing ionic flux and charge movement in skeletal muscle channels, using mutations of DIII-DIV linker charges. Charge altering and substituting mutations at K-1317, K-1318 depolarized the g(V) c...

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Identifiers

PMID: 17513361
DOI: 10.1529/biophysj.106.102079
PMCID: PMC1948039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17513361-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Charge immobilization of skeletal muscle Na+ channels: role of residues in the inactivation linker.PMID 17513361Read ↗

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