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Article

Structure-function studies of the C3a-receptor: C-terminal serine and threonine residues which influence receptor internalization and signaling.

European journal of immunology - 1 Apr 2003

Settmacher Britta, Rheinheimer Claudia, Hamacher Henning, Ames Robert S, Wise Alan, Jenkinson Lesley, Bock Daniel, Schaefer Myriam, Köhl Jörg, Klos Andreas

Abstract excerpt

The anaphylatoxic peptide C3a is a pro-inflammatory mediator generated during complement activation, whose specific G protein coupled receptor is expressed on granulocytes, monocytes, mast cells, activated lymphocytes, and in the nervous tissue. We have generated RBL-2H3 cell clones stably expressing mutants of the human C3a-receptor (C3aR) with combined alanine (Ala) substitutions of ten C-terminal serine (Ser)...

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PMID: 12672058
DOI: 10.1002/eji.200323293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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