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Article

Experimental evolution yields hundreds of mutations in a functional viral genome.

Journal of molecular evolution - 1 Sept 2003

Bull J J, Badgett M R, Rokyta D, Molineux I J

Abstract excerpt

Two lines of the bacteriophage T7 were grown to fix mutations indiscriminately, using a combination of population bottlenecks and mutagenesis. Complete genome sequences revealed 404 and 299 base substitutions in the two lines, the largest number characterized in functional microbial genomes so fa...

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Identifiers

PMID: 14629033
DOI: 10.1007/s00239-003-2470-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14629033-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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