Article
Instability of repeated dinucleotides in bacteriophage T7 genomes.
Mutation research - 5 Jul 1996
Yang Y, Masker W
Abstract excerpt
The ligase gene of bacteriophage T7 was interrupted with an insert of synthetic DNA that included a series of dinucleotide repeats which altered the reading frame of the gene and prevented the phage from growing on a host deficient in Escherichia coli ligase. The insert was designed so that gain of an additional copy of the repeat would restore the reading frame and produce ligase positive T7. It was found that a...
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