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Article

Directed evolution of an error-prone T7 DNA polymerase that attenuates viral replication.

Chembiochem : a European journal of chemical biology - 4 Jul 2011

Söte Sandra, Kleine Stefan, Schlicke Marina, Brakmann Susanne

Abstract excerpt

Experimental evidence exists that RNA viruses replicate with extremely high mutation rates that result in significant genetic diversity. The diverse nature of viral populations allows rapid adaptation to dynamic environments, and evolution of resistances to vaccines as well as antiviral substances. For DNA viruses that replicate at much greater fidelities, as yet, neither diverse structures in the population nor...

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Identifiers

PMID: 21626635
DOI: 10.1002/cbic.201000799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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