Article
Gene order constrains adaptation in bacteriophage T7.
Virology - 10 Oct 2005
Springman R, Badgett M R, Molineux I J, Bull J J
Abstract excerpt
The order of genes in the genome is commonly thought to have functional significance for gene regulation and fitness but has not heretofore been tested experimentally. We adapted a bacteriophage T7 variant harboring an ectopically positioned RNA polymerase gene to determine whether it could regain the fitness of the wild type. Two replicate lines maintained the starting gene order and showed only modest recovery...
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