Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis.

The American journal of pathology - 1 Apr 2007

Kopfstein Lucie, Veikkola Tanja, Djonov Valentin G, Baeriswyl Vanessa, Schomber Tibor, Strittmatter Karin, Stacker Steven A, Achen Marc G, Alitalo Kari, Christofori Gerhard

Abstract excerpt

In many human carcinomas, expression of the lymphangiogenic factor vascular endothelial growth factor-D (VEGF-D) correlates with up-regulated lymphangiogenesis and regional lymph node metastasis. Here, we have used the Rip1Tag2 transgenic mouse model of pancreatic beta-cell carcinogenesis to investigate the functional role of VEGF-D in the induction of lymphangiogenesis and tumor progression. Expression of VEGF-D...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Leukocytes
Share to Lymph Nodes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphangiogenesis

Share to Lymphatic Vessels

Share to Microscopy, Electron, Scanning

Share to Microscopy, Electron, Transmission

Share to Neovascularization, Pathologic

Share to Pancreatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 17392173
DOI: 10.2353/ajpath.2007.060835
PMCID: PMC1829467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis.PMID 17392173Read ↗

MFG-E8/Lactadherin Promotes Tumor Growth in an Angiogenesis-Dependent Transgenic Mouse Model of Multistage CarcinogenesisSemantic proximity Read ↗

Transformation of the microvascular system during multistage tumorigenesis.Semantic proximity Read ↗

VEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis.Semantic proximity Read ↗

Combined targeting of TGF-β, EGFR and HER2 suppresses lymphangiogenesis and metastasis in a pancreatic cancer model.Semantic proximity Read ↗

Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization.Semantic proximity Read ↗

Mechanisms of Tumor-Induced Lymphovascular Niche Formation in Draining Lymph NodesSemantic proximity Read ↗

Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.Semantic proximity Read ↗

Nintedanib Is a Highly Effective Therapeutic for Neuroendocrine Carcinoma of the Pancreas (PNET) in the Rip1Tag2 Transgenic Mouse Model.Semantic proximity Read ↗

[Mechanisms and role of lymphangiogenesis in cancer metastasis].Semantic proximity Read ↗

Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions.Semantic proximity Read ↗

Hypoxia inducible factor-1α is necessary for invasive phenotype in Vegf-deleted islet cell tumors.Semantic proximity Read ↗

Establishment of a new human pancreatic cancer cell line, NOR-P1, with high angiogenic activity and metastatic potential.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.