Macrophages regulate the angiogenic switch in a mouse model of breast cancer.

doi:10.1158/0008-5472.CAN-06-1278

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Article

Macrophages regulate the angiogenic switch in a mouse model of breast cancer.

Cancer research - 1 Dec 2006

Lin Elaine Y, Li Jiu-Feng, Gnatovskiy Leoid, Deng Yan, Zhu Liyin, Grzesik Dustin A, Qian Hong, Xue Xiao-nan, Pollard Jeffrey W

Abstract excerpt

The development of a tumor vasculature or access to the host vasculature is a crucial step for the survival and metastasis of malignant tumors. Although therapeutic strategies attempting to inhibit this step during tumor development are being developed, the biological regulation of this process is still largely unknown. Using a transgenic mouse susceptible to mammary cancer, PyMT mice, we have characterized the...

Topics

Animals
Blood Vessels
Disease Progression
Genotype
Green Fluorescent Proteins
Macrophage Colony-Stimulating Factor
Macrophages
Mammary Neoplasms, Animal
Mice
Mice, Knockout
Mice, Transgenic
Neovascularization, Pathologic
Receptor, Macrophage Colony-Stimulating Factor

Source

Open in PubMed

Identifiers

PMID: 17114237
DOI: 10.1158/0008-5472.CAN-06-1278

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