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Article

Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform.

Nature communications - 6 Jul 2020

Kutys Matthew L, Polacheck William J, Welch Michaela K, Gagnon Keith A, Koorman Thijs, Kim Sudong, Li Linqing, McClatchey Andrea I, Chen Christopher S

Abstract excerpt

The mammary gland is a highly vascularized tissue capable of expansion and regression during development and disease. To enable mechanistic insight into the coordinated morphogenic crosstalk between the epithelium and vasculature, we introduce a 3D microfluidic platform that juxtaposes a human mammary duct in proximity to a perfused endothelial vessel. Both compartments recapitulate stable architectural features...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32632100
DOI: 10.1038/s41467-020-17102-x
PMCID: PMC7338408

Genes

ERBB2
PIK3CA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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