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Article

Preclinical murine tumor models: A structural and functional perspective

28 Jan 2020

Abstract excerpt

The goal of this review is to pinpoint the specific features, including the weaknesses, of various tumor models, and to discuss the reasons why treatments that are efficient in murine tumor models often do not work in clinics. In a detailed comparison of transplanted and spontaneous tumor models, we focus on structure-function relationships in the tumor microenvironment. For instance, the architecture of the...

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PMID: 31990272
DOI: 10.7554/elife.50740

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