Article
Co-clinical Analysis of a Genetically Engineered Mouse Model and Human Prostate Cancer Reveals Significance of NKX3.1 Expression for Response to 5α-reductase Inhibition.
European urology - 1 Oct 2017
Dutta Aditya, Panja Sukanya, Virk Renu K, Kim Jaime Yeji, Zott Roseann, Cremers Serge, Golombos David M, Liu Deli, Mosquera Juan Miguel, Mostaghel Elahe A, Barbieri Christopher E, Mitrofanova Antonina, Abate-Shen Cory
Abstract excerpt
BACKGROUND: Although men on active surveillance for prostate cancer (PCa) may benefit from intervention with 5α-reductase inhibitors (5-ARIs), it has not been resolved whether 5-ARIs are effective for delaying disease progression and, if so, whether specific patients are more likely to benefit. OBJECTIVE: To identify molecular features predictive of patient response to 5-ARIs. DESIGN, SETTING, AND PARTICIPANTS:...
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