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Article

Gata3 antagonizes cancer progression in Pten-deficient prostates

20 Feb 2013

Abstract excerpt

Loss of the tumor suppressor PTEN is a common occurrence in prostate cancer. This aberration leads to the ectopic activation of the PI3K-Akt pathway, which promotes tumor growth. Here, we show that the transcription factor Gata3 is progressively lost in Pten-deficient mouse prostate tumors as a result of both transcriptional down-regulation and increased proteasomal degradation. To determine the significance of...

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PMID: 23428429
DOI: 10.1093/hmg/ddt088

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