Dictyostelium LvsB mutants model the lysosomal defects associated with Chediak-Higashi syndrome.

doi:10.1091/mbc.01-09-0454

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Dictyostelium LvsB mutants model the lysosomal defects associated with Chediak-Higashi syndrome.

Molecular biology of the cell - 1 Feb 2002

Harris Edward, Wang Ning, Wu Wl Wei-l, Weatherford Alisha, De Lozanne Arturo, Cardelli James

Abstract excerpt

Chediak-Higashi syndrome is a genetic disorder caused by mutations in a gene encoding a protein named LYST in humans ("lysosomal trafficking regulator") or Beige in mice. A prominent feature of this disease is the accumulation of enlarged lysosome-related granules in a variety of cells. The genome of Dictyostelium discoideum contains six genes encoding proteins that are related to LYST/Beige in amino acid...

Topics

Animals
Chediak-Higashi Syndrome
Dictyostelium
Humans
Lysosomes
Mice
Mutation
Protein Structure, Tertiary
Proteins
Protozoan Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 11854420
DOI: 10.1091/mbc.01-09-0454
PMCID: PMC65657

Genes

LYST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics