Article
Altered composition and secretion of lysosome-derived compartments in Dictyostelium AP-3 mutant cells.
Traffic (Copenhagen, Denmark) - 1 Apr 2008
Charette Steve J, Cosson Pierre
Abstract excerpt
Genetic alteration of the adaptor protein (AP)-3 complex is responsible for the type 2 Hermansky-Pudlak syndrome, a lysosomal storage disease similar to the Chediak-Higashi syndrome (CHS). AP-3 presumably participates in the biogenesis of late endosomal compartments and may also be critical for the regulated secretion of lysosomes by specialized cells. Here, Dictyostelium discoideum cells defective for the mu3...
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